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Friday, 7 September 2018
Urgent Openings in Regulatory Affairs @ HETERO Biopharma
Urgent Openings in Regulatory Affairs @ HETERO Biopharma
Thursday, 10 May 2018
SOP OF Determination Of NOISE
Principle:
To describe the general test method for measurement of noise.
To describe the general test method for measurement of noise.
Scope:
This work instruction is applicable for measurement of noise at various locations.
This work instruction is applicable for measurement of noise at various locations.
Procedure:
INSTRUMENT: Environmental
noise pollution monitor
Test method:
Switch on the
instrument by DC switch.
Check the
instrument for 94 dB(A) for its normal operation before taking for measurement
Place the monitor
in such a way that the sensor of the monitor is facing the noise.
Keep the setting
of four switches as under
ON / OFF -
ON (DC)
Range 50
- 100
Selector switch - A
Hold max - F
Equipment directly
indicates the noise level.
Record the
observation.
SOP Of Temperature
Scope:
Prescribes method for the measurement of temperature of water & waste water.
Principle:
Temperature measurements may be made with any mercury-in-glass thermometer, provided it is checked occasionally against a precision thermometer certified by a competent agency. Depth temperature may be obtained with a protected reversing thermometer or a thermister. Measurements of temperature are, usually, more conveniently done using thermistors.
Procedure:
Make measurement with the
thermometer immersed directly in the water body, after a period of time
sufficient to permit constant reading. If the measurement of water temperature
cannot be carried out directly, carry it out in a sampling bottle. The bottle
should have a volume of at least one litre. Adjust its temperature to that of
the sample water before the measurement. Do not expose it to heat or direct
solar radiation. Measure temperature of tap water in a bottle through the water
flows until a constant reading is obtained. Make measurement of the
temperature of a water body at a particular depth with the thermometer or
thermistor immersed directly in the water body. After sufficient time has
elapsed to allow the thermometer or thermistor to come to the exact temperature
of the water, take a reading. In the case of the thermistor make a direct
measurement of its resistance & obtain the temperature of the water body
from the calibration curve supplied with the thermistor.
In the case of reversing
thermometer, obtain the reading by dropping a messenger weight along the wire
to which is attached the reversing thermometer in a reversing frame on a water
sampling bottle. This weight normally drops at a speed of about 150 meters per
minute except when the wire is extremely inclined to the vertical. After
sufficient time has passed for the messenger weight to trip the thermometer,
haul up the wire & keep the water bottle with the thermometer carefully in
a vertical position away from direct sunlight in order to prevent accidental
reversing before reading the temperature to be measured. Allow about 10 to 15
minutes for the thermometers to reach the air temperature, after they are
brought up from the water. At this stage the auxiliary thermometer records the
atmospheric temperature & the main thermometer, the approximate temperature
of the water body.
Calculations: Calculate the exact temperature of the water body, in the case
of the reversing thermometer, from the following formula:
Tw = T΄+C+l& C = (T΄-Vo) (T΄-T1) / K – 100
Where
Tw = The corrected value, that is, the true value of the water temperature, °C
T’ – the reading of the main thermometer , °C
I - the index correction given on a calibration sheet supplied with the thermometer
C- correction for thermal expansion
V0 – volume of mercury below 0°C mark given on the calibration graph
K – reciprocal thermal expansion coefficient given on the calibration graph, and
T1 – temperature reading of the auxiliary thermometer , °C
If an unprotected reversing thermometer is used along with the protected thermometer the corrected temperature Tu can be similarly obtained. The actual depth of reversal of the thermometers can be obtained using the following equation
Z = Tu – T w
Pm – Q
Where,
Z = depth in metres
Tu = corrected reading of the protected thermometer, °C
Tw = corrected reading of the protected thermometer , °C
Pm = mean density of the water column
Q = pressure coefficient of the unprotected thermometer given on the
calibration graph
Report the temperature of water to the nearest 0.01 , 0.1 or 0.5°C , depending on the accuracy required and the thermometer used.
SOP OF ESTIMATION OF ODOUR
PREPARATION OF APPARATUS:
Thoroughly clean the required number of wide-mouth glass Stoppered bottles of about one litre capacity. Rinse them with hydrochloric acid and render them completely odourless by repeated washing with odour free distilled water through a column of granulated activated carbon.
PROCEDURE:
As soon as possible after collection of sample, fill a bottle, half full of sample, insert the stopper, shake vigorously for 2 to 3 seconds and then clean quickly observe the odour. The sample taken for observation of odour shall be at room temperature.
REPORT:
Report the true odour of the sample at the mouth of the bottle as rotten egg, burnt sugar, soapy, fishy, septic, aromatic, chlorinous, alcoholic odour or any other specific odour. In case it is not possible to specify the exact nature of odour, report as agreeable or disagreeable.
Thoroughly clean the required number of wide-mouth glass Stoppered bottles of about one litre capacity. Rinse them with hydrochloric acid and render them completely odourless by repeated washing with odour free distilled water through a column of granulated activated carbon.
PROCEDURE:
As soon as possible after collection of sample, fill a bottle, half full of sample, insert the stopper, shake vigorously for 2 to 3 seconds and then clean quickly observe the odour. The sample taken for observation of odour shall be at room temperature.
REPORT:
Report the true odour of the sample at the mouth of the bottle as rotten egg, burnt sugar, soapy, fishy, septic, aromatic, chlorinous, alcoholic odour or any other specific odour. In case it is not possible to specify the exact nature of odour, report as agreeable or disagreeable.
ODOUR
CLASSIFIED BY CHEMICAL TYPES
ODOUR
CHARACTERISTICS
SWEETNESS
(1)
|
PUNGENCY
(2)
|
SMOKINESS
(3)
|
ROTTENNESS
(4)
|
ODOUR
CLASS (5)
|
100
|
50
|
0 to 50
|
50
|
Estery
|
100
|
50 to 100
|
0 to 100
|
50
|
Alcoholic
|
50
|
50
|
0 to 50
|
50
|
Carbonyl
|
50
|
100
|
0 to 50
|
50
|
Acidic
|
100
|
50 to 100
|
50 to 100
|
0 to 100
|
Halide
|
50
|
50
|
100
|
100
|
Sulphury
|
100
|
50
|
50
|
100
|
Unsaturated
|
100
|
50
|
0 to 50
|
100
|
Basic
|
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